Deri hastalıkları bazen birbirini taklit edebilir ya da hastalık kendine ait tipik klinik özellikleri göstermez. Ya da bazen hastalığın iyi huylu olup olmadığından şüpheye düşeriz. Bu durumlarda deri biyopsi alma işlemi gerekebilir. Lokal anestezi ile sıklıkla 3 mm kadar küçük boyutlarda deri biyopsileri alınır ve patolojiye gönderilir. Patolojiden gelen sonuca göre tanı ve tedavi planlanır.
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